Pain, inflammation, fever (prostaglandin synthesis inhibition).
Children: 10–15 mg/kg/dose q 4–6 hr.
Adults: 650–1,000 mg/dose q 4–6 hr (max: 4 g/24 hr)

Kawasaki disease (acute phase).
Children: 80–100 mg/kg/24 hr divided q 6 hr.

Rheumatic fever.
60–100 mg/kg/24 hr divided q 6 hr.